Morphea pathology outlines. Pasini described it in 1923 under the name of ”progressive idiopathic atrophoderma. Variable elastic fiber changes have been described, but to our knowledge, no systematic study of the elastic fiber pattern correlated with CD34 expression has been reported. Jul 1, 2011 · Eosinophilic infiltration of hair follicle; follicular epithelium is spongiotic, adjacent dermis has lymphocytic and eosinophilic infiltrate. Solar lentigines are benign lesions occurring on sun- exposed skin. Related to meningioma of skin. We present six cases of morphea in which typical Extrahepatic bile duct nonneoplastic and tumors: biliary intraepithelial neoplasia carcinoma of extrahepatic bile ducts choledochal cyst intraductal papillary neoplasm of biliary tract traumatic neuroma. Morphea profunda, eosinophilic fasciitis, and disabling pansclerotic morphea of children are included in this group, but overlapping of the extent and depth of cutaneous involvement Feb 3, 2021 · Fig 1. Local aggressive course. ICD-11: XH4NK2 - chondroblastoma, NOS. In children, the linear subtype predominates while in adults’ plaque and generalized subtypes are most common. Lasts 3 - 4 weeks, then virus tracks along regional nerves and becomes dormant in trigeminal or other local ganglia. Case 2 —A 45-year-old male presented with a 1-year history of hyperpigmentation around the neck and lower face, which worsened with sweating and during summer. Oct 24, 2023 · Pigmented purpuric lichenoid dermatitis of Gougerot and Blum. Clinically, the presence of erosions, oral involvement, a burning sensation or a hyperkeratotic lesional margin favor a diagnosis of lichen planus over lichen sclerosus (Australas J Dermatol 2020;61:324) Sample pathology report. Multiple ulceration, at least 1 on anterior lower leg. Although rarely fatal, BCC can be highly destructive and disfigure local tissues when treatment is Clement: Atlas of Gynecologic Surgical Pathology, 4th Edition, 2019, Surg Pathol Clin 2019;12:249 Board review style question #1 The image above shows an example of HPV independent squamous cell carcinoma of the vulva in association with differentiated vulvar intraepithelial neoplasia. Nov 1, 2019 · Microscopic description: A folliculocentric tumor with bulbous profile and stromal clefting is seen in the dermis with connection to the epidermis. A single-institution retrospective cohort study was conducted. Lupus panniculitis. Oct 18, 2021 · Sheets of chondroblasts admixed with osteoclast-like giant cells and eosinophilic chondroid matrix; pericellular chicken wire type calcification may be present. Atrophic lesions: skin is smooth, wrinkled and soft. The absence of antinuclear antibodies (ANA), Raynaud’s phenomenon and capillaroscopic anomalies constitutes an important element of differential diagnosis with systemic Infestations: infestations-general body & pubic louse brown recluse spider cutaneous larva migrans demodex dirofilariasis myiasis onchocerciasis scabies (mite) tick bite Tunga penetrans. Low disease associated death rate; metastases to lung and bone exceptionally rare. edu. Jan 30, 2023 · Erosion: Discontinuity of skin causing partial loss of epidermis. Herpes simplex: Historically, HSV1 was associated with herpes labialis (90%), and HSV2 was associated with herpes genitalis (90%), although in some recent studies, most genital lesions are caused by HSV1. Panniculitis: alpha-1-antitrypsin deficiency panniculitis calciphylaxis encapsulated fat necrosis erythema induratum (pending) erythema nodosum inflammation should be included in pathology reports to help aid in clinical management. Itching is frequently severe, especially in anogenital area. Lichenoid and violaceous plaques with superimposed purpura, 1 to several centimeters in diameter, pruritic, may resemble Kaposi sarcoma, bilateral, chronic. Histologically, there is a conspicuous bulb-like elongation of rete ridges that Aug 1, 2011 · Palisading, necrobiotic granuloma consist of a large confluent area of necrobiosis centered in the superficial dermis and subcutaneous fat. 1%, 11/99, P < . Graft versus host disease (GVHD) is a multisystem immunologic disorder following an allogenic hematopoietic cell transplant and rarely after solid organ transplant or transfusion. Acanthosis and papillomatosis (A) are features of seborrheic keratosis but can also be seen in squamous cell carcinoma. Nevus verrucosus (verrucous epidermal nevus Mar 1, 2020 · Morphea, also known as localized scleroderma, is a sclerosing disease of unknown etiology that involves mainly dermal and subcutaneous. Jan 10, 2022 · Morphea profunda or subcutaneous (deep) morphea is a variant of localized morphea, characterized by one or more ill-defined, deep sclerotic plaque. Pathogenesis is related to repeated intermittent sun exposure and ultraviolet-induced mutations leading to enhanced melanin production and abnormal pigment retention by keratinocytes. Follicular mucinosis may rarely be seen. Morphea, also known as localized scleroderma, encompasses a group of idiopathic sclerotic skin diseases. Erythema induratum. Generalized morphea is the most severe form of localized morphea [5, 6]. International criteria for Behçet disease - point score system: scoring ≥ 4 indicates Behçet diagnosis ( J Eur Acad Dermatol Venereol 2014;28:338 ) Ocular lesions: 2 points. Over time the patches may become firm, dry and smooth. Lipodermatosclerosis (hypodermitis sclerodermiformis and sclerosing panniculitis) presents as a chronic fibrosing disease commonly associated with venous insufficiency, arterial ischemia or thrombophlebitis. K36M mutations commonly identified. Scleroderma: In this condition the overlying epidermis and superficial dermis is spared. 1 This disease is characterized by sclerosis of the skin and subcutaneous tissue, resulting from chronic inflammation and deposition of collagen and extracellular matrix proteins. Erosions may progress to become open, non healing wounds and Solar lentigo. X linked variant: deficiency in steroid sulfatase, which removes proadhesive Sep 1, 2012 · Definition / general. Due to systemic small vessel leukocytoclastic vasculitis. Pathergy. Jul 1, 2021 · Morphea (localized scleroderma) is a rare fibrosing disorder of the skin and underlying tissues, with an estimated incidence of 2. History of papule, pustule, vesicle within 4 days of ulceration. Atypical mitotic figures (B) are a feature of squamous cell carcinoma. Address: UCLA Med-Derm 200 Medical Plaza, Suite 450 Los Angeles, CA 90095. Eventually converts into multinodular goiter. Familial cases have been described. Other nonneoplastic lesions: calcification ectopic decidual reaction endometriosis endosalpingiosis cortical inclusion cyst polycystic ovary disease torsion. Jun 1, 2016 · Lice: intense itching and irritation, erosion, serous crusting and scaling of the scalp or other areas of the body. Most common malignant tumor type in humans. Nov 20, 2021 · Scleroderma-like disorders include a set of entities involving cutis, subcutis and, sometimes, even muscular tissue, caused by several pathogenetic mechanisms responsible for different clinical–pathological pictures. The pigment is melanin, which is positive with the Fontana-Masson stain but not Prussian blue. History of inflammatory bowel disease or inflammatory arthritis. See full list on cme. ucla. The overlying epidermis demonstrates hyperkeratosis. Usually caused by dermatophytes; in children, usually due to Trichophyton Differentiate metastatic colorectal adenocarcinomas (SATB2+) from pancreatobiliary neoplasms (SATB2-) ( Am J Clin Pathol 2021;155:124 ) Differentiate ovarian metastases of colorectal and appendiceal origin (SATB2+) from primary ovarian tumors of mucinous or endometrioid type (SATB2-) ( Am J Surg Pathol 2016;40:419 ) May 17, 2022 · Tumor cells show focal SMA and CD34 positivity, whereas desmin, caldesmon, S100 and pancytokeratin are negative. Introduction: Morphea is a chronic autoimmune fibrosing condition of the skin and underlying tissue with the potential for significant disease-associated morbidity. Feb 1, 2015 · Historically there has been controversy as to whether Stevens-Johnson syndrome (SJS) is a distinct entity or at the center of the disease spectrum that includes erythema multiforme (EM) and toxic epidermal necrolysis (TEN) Currently, there is an increasing trend for SJS and TEN as representing the ends of a spectrum of severe epidermolytic Sep 21, 2023 · SynopsisCopy. Aug 25, 2022 · Morphea (mor-FEE-uh) is a rare condition that causes painless, discolored patches on your skin. lww. In 2001, a group of hair clinicians, pathologists and researchers, under the rubric of the North American Hair Research Society (NAHRS), issued a consensus Definition / general. 1985; 7:207–221. Multinodular goiter: irregular enlargement of thyroid gland due to repeated episodes of hyperplasia and involution (degeneration) of simple goiter. Adult Aug 7, 2023 · Atrophoderma of Pasini and Pierini is a rare, cutaneous condition that causes dermal atrophy. Lymphoid follicles with germinal centers were also noted. Also called rudimentary meningocele or hamartoma of scalp with ectopic meningothelial elements. M orphea (localized scleroderma) is char-acterized by thickening of the skin re-sulting from inflammation and the Morphea, also known as localized scleroderma, is a disorder characterized by excessive collagen deposition leading to thickening of the dermis, subcutaneous tissues, or both. Jul 1, 2011 · Definition / general. Feb 11, 2022 · Board review style answer #2. Linear morphea en coup de sabre is a localized form of morphea that presents as paramedian face or frontal scalp depression. [1] It is an idiopathic, gradually progressive craniofacial asymmetry, following the atrophy of subcutaneous tissue, muscles, osseous, and cartilaginous structures. Nevus sebaceus of Jadassohn (sebaceous nevus, organoid nevus) is a hamartoma that is histologically characterized by a complex and abnormal proliferation of epidermis and adnexal structures. Usually epithelioid histiocytes, giant cells and sometimes a well formed granuloma. Tungiasis: subcutaneous nodules, rashes or ulcer. Peripheral palisading and a thickened basement membrane is noted. Histologic features are identical to that of BCC occurring elsewhere on the skin. Rare primary mucinosis that presents with nonpitting indurated edema and associated dermal hardening in the absence of any clinical abnormality. Z - benign chondrogenic tumors, site unspecified. Urticaria pigmentosa: common form of mastocytosis, numerous small yellow brown papules, become hives when rubbed. Linear morphea was the most common morphea subtype (50. They resist hyaluronidase digestion. Sep 3, 2020 · Dilated small intestinal lacteals, which may be primary or secondary. Lobular: Infectious panniculitis. Histopathological evaluation of skin biopsies and laboratory tests are not necessary in the majority of morphea cases. Promastigotes transform in these cells into the tissue stage of the parasite (i. Typically, the skin changes appear on the belly, chest or back. We are proud of the numerous testimonials we receive, both from pathologists and advertisers. We found the morphea transcriptome is dominated by IFN-γ Mar 16, 2017 · The diagnosis of morphea is often based on characteristic clinical findings. Definition / general. Most cutaneous mast cell disorders have a good prognosis. While the exact etiology of morphea is not fully elucidated, many studies have explored the immunologic drivers of this disease. Areas covered: Using PubMed, we performed Morphea (localized scleroderma) is a disease of unknown etiology, presenting as circumscribed areas of indurated skin. The histopathology of alopecia in linear morphea is typically characterized by sclerosis and a reduction in the number of follicular units. Macular amyloidosis: focal / small amounts of eosinophilic faceted deposits in papillary dermis; also pigment incontinence. References: Pathol Annu 1995;30:95, Histopathology 2011;58:811. Lichenoid amyloidosis: hyperkeratosis, acanthosis, basal hydropic degeneration; small eosinophilic globules in Mar 5, 2024 · Morphea, also known as localized scleroderma, is an idiopathic inflammatory disorder that causes sclerotic changes in the skin. ) Key words: morphea; pain; pathology; sclerosis; severity; symptoms. The inflammatory infiltrate is typically sparse and around deep adnexal and vascular structures. It is known to affect the subcutis of the lower extremities, commonly in obese, white women, older than 60. Read more >>. Sep 1, 2012 · Definition / general. However, the clinical presentation, absence of preceding inflammation, induration, or scleroderma and absence of dermal sclerosis on histopathologic examination, led to a diagnosis of LAM. It is a malignant soft tissue sarcoma with high risk of local recurrence if inadequately excised. This diagnostic category is justified because the recurrence and progression rates of papillary urothelial neoplasm of low malignant potential (PUNLMP) are expected to be higher than urothelial papilloma and lower than low grade noninvasive urothelial carcinoma. Clinically manifests as a congenital, yellow-orange mamillated patch / plaque with alopecia typically occurring on the scalp and face. The following clinical diagnostic criteria for this subtype of morphea must be fulfilled: four or more lesions larger than 3 cm in diameter or involvement of two or more of the seven body areas (the head and neck, the right and left upper extremities, the anterior and posterior trunks, and the right and left lower Jan 30, 2024 · Definition / general. Mastocytosis: monomorphic population of mast cells with rare eosinophils. Epidemiology. Subcutaneous fat necrosis of the newborn. Nov 2, 2021 · Gastric type and clear cell carcinomas are known to be HPV independent. Presence of multiple epidermal inclusion cysts has been documented in Gardner syndrome , a variant of familial adenomatous polyposis with benign osteomas and intestinal fibromatoses. Adam Norberg, MS3 - ANorberg@mednet. Pancreatic panniculitis. Mar 13, 2019 · Morphea may present at any age. Follicular orifice becomes plugged with bacteria and keratin, leading to cystic dilation and entrapment of keratin debrisÂ. 5-year history of linear Scleroderma panniculitis, also morphea profunda. Can be associated with secondary infections. Scalp and beard lesions may have superimposed bacterial folliculitis / perifolliculitis. Superpages: entire chapter images virtual slides. Morphea profunda. 7 per 100,000 individuals. Superficial dermal perivascular mononuclear and eosinophilic infiltrate. Index (Alphabetical table of contents) Seborrheic keratosis is a benign keratinocyte proliferation that lacks atypia and dysplasia. Its etiology is not fully understood, but it is believed that there is genetic predisposition, in addition to environmental triggering factors. , amastigotes) Parasite, host and other factors affect Morphea, or localized scleroderma, is a rare disease of the connective tissue that manifests itself with localized sclerosis of the skin and, in some cases, with extracutaneous manifestations. (J Am Acad Dermatol 2017;76:1124-30. Morphea profunda is a type of panniculitis. After viral infection, especially UTI or insidious onset with no prior acute illness. Nov 15, 2021 · Exclude infection. Tumor-like lesions: corpus luteum cyst fibromatosis and massive edema follicle cyst hyperreactio luteinalis large solitary luteinized follicular cyst of pregnancy and puerperium Leydig Nov 8, 2022 · Parry Romberg syndrome (PRS), also referred to as progressive hemifacial atrophy, progressive facial hemiatrophy, or idiopathic hemifacial atrophy, was first described by C Parry and M Romberg. In our patient, the initial clinical diagnosis was linear morphea. Also called cold sore. Differential diagnosis of lichen sclerosus pathology. Many seborrheic keratoses have mutations in FGFR3 (D) but it Morphea, also known as localized scleroderma, is a rare fibrosing disorder of the skin and underlying tissues. The presence of hyperplastic lymphoid follicles in the context of the sclerotic bands of morphea is rarely described. During the early stage of generalized morphea there is an inflammatory reaction involving primarily the fat around the eccrine sweat glands and the subcutaneous tissue. Jan 8, 2016 · Atrophoderma of Pasini and Pierini is considered an abortive variant of morphea. e1 ) Nulliparous females ( Cancer 1985;56:403, Am J Epidemiol 2008;168:563 ) Oct 20, 2022 · Essential features. Rusty yellow or gold lichenoid papules, patches and plaques, unilateral, acute onset, persistent course. Peripheral erythema, undermining border and tenderness. 6%, 55/192) than those without (11. Skin, left lower leg, shave biopsy: Lichen simplex chronicus (see comment) Comment: Sections demonstrate hyperkeratosis, focal parakeratosis Jun 1, 2013 · Herpes simplex virus. Usually in people of African descent, often in earlobe. Extensive on the scalp. May be surrounded by an erythematous to violaceous halo. Ichthyosis vulgaris: common type. 2, 3 Because morphea can lead to substantial morbidity Abstract. Spongiotic dermatitis. Morphea patients who had a biopsy in 2005–2015 were included, and a histopathological review was conducted by 2 Oct 10, 2023 · Definition / general. Primary intestinal lymphangiectasia is a rare disorder resulting in lymph leakage into the small bowel lumen and responsible for protein losing enteropathy, leading to lymphopenia, hypoalbuminemia and hypogammaglobulinemia ( Orphanet J Rare Dis 2008;3:5 ) May 9, 2019 · Pathophysiology. e. Apr 5, 2023 · Morphea is an inflammatory fibrotic disorder of the skin that has been likened to systemic sclerosis (SSc). Norberg and Levins had full access to all of the data in the study and take responsibility for the integrity of the clinical vignette Jun 22, 2023 · A. Jan 28, 2020 · This is an adenomatoid tumor, which is of mesothelial origin as the staining pattern suggests. Telangiectasia macularis eruptive perstans (TMEP): telangiectatic light or dark brown macules. Most infected adults have latent HSV1 that is activated by upper respiratory infection, excessive exposure to cold, wind, sun, allergies. Atrophoderma of Pasini and Pierini usually first appears in adolescence or early adulthood (second and third decade). Eosinophilic Fasciitis. Contact us at (248) 646-0325 with any questions. Excoriation: Deep scratch with abrupt loss of epidermis without full thickness loss at an ulcer. [ 1 Jul 8, 2022 · Definition / general. Signs: Koebner phenomenon: new psoriatic papules at sites of skin trauma. The term 'scleroderma' covers various types of morphoea and systemic sclerosis . Morphea is differentiated from systemic sclerosis based on the absence of sclerodactyly, Raynaud phenomenon, and nailfold capillary changes. Helminths: subcutaneous nodules, rashes or ulcer. Subtypes of morphoea vary according to the Nov 20, 2021 · Morphea, also known as localized scleroderma, manifests with single or multiple areas of cutaneous sclerosis, with varying morphology. Recurrence rate: 18 - 20% ( Am J Clin Pathol 2010;133:788, Diagn Pathol 2015;10:3 ) Deep morphea encompasses a variety of clinical entities in which inflammation and sclerosis are found in the deep dermis, panniculus, fascia, or superficial muscle. The present study, referred to as the MAC cohort (Morphea in Adults and Children), was designed to examine demographic, clinical, and histological features in a thoroughly-phenotyped cohort of participants with morphea. Nonpitting, woody induration of upper back skin; associated with diabetes. Due to pathogens restricted to the stratum corneum, with little or no tissue reaction. 1097/00000372-198506000-00002. Patients with morphea commonly have systemic symptoms, such as malaise, fatigue, arthralgias Apr 4, 2022 · Pathophysiology. Scalp nodule that often arises during infancy containing meningothelial cells; may be diagnosed later in life. Jul 1, 2011 · In adults, is associated with malignancies (lymphoma, carcinoma of bronchus, breast and cervix), sarcoidosis, lupus and drugs. Genital aphthosis: 2 points. doi: 10. Onset in infancy, childhood, and late adult-life has been reported, as has congenital presentation. Subacute cutaneous lupus erythematosus (SCLE) presents clinically as a photosensitive, nonscarring, nonatrophy producing eruption. Drug induced in 30% of cases ( Br J Dermatol 2012;167:296 ) Jul 21, 2015 · Takei Y, Fukushiro S, Ackerman AB. Am J Dermatopathol. 001). Eosinophilic, swollen or degenerate collagen appears hyalinised with surrounding infiltrate of lymphocytes and histiocytes. Dec 7, 2023 · Clinical features. But they might also appear on your face, arms and legs. com Nov 11, 2020 · Morphea (localized scleroderma) is a rare fibrosing disorder of the skin and underlying tissues, with an estimated incidence of 2. Morphea, also known as localized scleroderma, is a rare fibrosing disorder of the skin and underlying tissues. Page views in 2024 to date: 1,780,751. Gallbladder stains: CK7 CK19 CK20 DPC4 / SMAD4. Noninvasive epithelial neoplasm of the gallbladder that forms pedunculated polyps composed exclusively of small, nonmucinous tubules, often with squamoid morules ( Virchows Arch 2021;478:435 ) Despite the cytoarchitectural complexity that warrants high grade dysplasia diagnosis, almost never associated with invasion Jun 11, 2021 · Thyroid gland usually 40 g or more. Visceral involvement is most often seen Sep 19, 2022 · Basal cell carcinoma (BCC), previously known as basal cell epithelioma, is the most common cancer in Humans. Atopic dermatitis may be categorized depending on the phase of the disease. It can be acute or chronic and can affect many organ systems, including the skin, gastrointestinal tract, liver and lungs. Dec 7, 2023 · Epidermal nevi typically present as multiple warty brown patches or plaques along the lines of Blaschko. It presents as single or multiple, sharply demarcated, hyperpigmented, non-indurated patches with no obvious Aug 1, 2011 · Definition / general. Also abdominal pain, vomiting, GI bleeding, arthralgias, hematuria, proteinuria and nephrotic syndrome. The tumor is composed of basaloid cells and cells with clear cytoplasm. Vulvar BCC is rare. Cystitis glandularis appears as irregular or nodular lesions with a cobblestone pattern or as a polypoid mass. Morphea is classified into circumscribed, generalized, linear, and pansclerotic subtypes according to the clinical presentation and depth of tissue involvement. The pathogenesis of morphea is not fully understood, but autoimmune dysfunction and imbalance of collagen Definition / general. Morphological features and immunoprofile strongly support the diagnosis of high grade myxofibrosarcoma. It is also known as localised scleroderma. Histologically, most cases of morphea feature thickened collagen bundles in the deep reticular dermis, sometimes also extending into the superficial dermis or into the subcutis. PathologyOutlines. Oral aphthosis: 2 points. Jul 1, 2013 · In the present study, secondary alopecia was seen in 8 cases, of which there were 4 cases of morphea and one each case of lupus vulgaris, congenital absence of skin, burn and sarcoidosis. Basal cell carcinoma (BCC) arises from the interfollicular or follicular epithelium. Skin lesions: 1 point. Basal cell carcinoma is usually a slow-growing tumor for which metastases are rare. Associated anti-SSA / Ro autoantibodies (40 - 100%); anti-SSB / La antibodies are often present as well. Histologic features are similarly variable, and skin biopsies may be nondiagnostic. com, free, updated outline surgical pathology clinical pathology Abstract. Healing is associated with postinflammatory hyperpigmentation. Typically affects the interdigital nerve that innervates the third webspace ( Radiographics 1999;19:1253 ) Strong predilection for middle aged women ( Foot Ankle 1983;3:238 ) Characterized microscopically by nerve fiber degeneration and excessive intraneural and perineural fibrosis. BCC mostly arises on sun-damaged skin and rarely develops on the mucous membranes or palms and soles. layers of skin. Positive for Fontana-Masson and CD34. Morphea is an autoimmune skin disease with protean clinical manifestations. These plaques eventually become inactive, leaving permanent dermal or soft Mar 2, 2021 · Diagnosis. The stroma is variably myxoid to collagenous, with scattered lymphocytes and extravasated erythrocytes. There is a strong female predominance (2-6:1) and most reports have been in Caucasians. Lichen planus: The presence of a well Supplementary concepts. 3%, 187/291) than other morphea subtypes. True endometrioid carcinoma of the cervix is exceedingly rare and likely arises from cervical endometriosis. Endometrioid carcinoma is no longer a recognized subtype of HPV associated adenocarcinoma, as it leads to confusion with the usual type. Superfical fungal infections may also be found on neoplastic skin lesions. Several types of morphea exist and various Feb 11, 2021 · Psoriatic arthritis: inflammation of distal interphalangeal joints and proximal interphalangeal joints of the feet and hands. 5, colloidal iron, and metachromatic dyes. Epidermal nevi can form a linear or zosteriform lesion. Thyroid gland often 100 g or more; may resemble a neoplasm, particularly if a single firm dominant nodule is present. Cystitis cystica appears as translucent submucosal cysts, mostly < 5 mm diameter. However, full-thickness skin biopsies, containing fascia and muscle tissue, are required for the diagnosis of EF. Background: Scleroderma/morphea is characterized by expansion of the dermis with thickened collagen bundles and loss of CD34 (+) dermal dendrocytes. Plaque morphea is characterized by ivory-white oval lesions with a lilac peripheral ring and a smooth surface asymmetrically distributed on the trunk or, less commonly, on the extremities; the face and fingers Definition / general. Mucin types include acid mucins and neutral mucins. ICD coding. Home page (desktop + mobile): Page views in 2023: 4,952,237. Basal cell carcinoma (BCC) arises from epithelial cells of either epidermis or hair follicle stem cells. ICD-11: 2E82. This is an example of pigmented dermatofibrosarcoma protuberans (Bednar tumor). High rate of recurrence after excision. Case 1: Superficial morphea: A 28-year old female with hyper- and hypopigmented atrophic, painful, shiny patches in the bilateral intertriginous areas. Morphea occurs more frequently in women, especially in adults where female predominance is marked (5:1). The patient presentation of a small painless mass in a patient in the third - fourth decade is typical. Acute: ill defined, oozing, crusted, eroded papules or vesicles on erythematous plaques. Alpha1-antitrypsin deficiency. Similar to that of endometrial endometrioid adenocarcinoma. Lesions on dark skinned individuals may appear as hypopigmentation or have follicular accentuation. Preferential sites are the abdomen, trunk, sacral area, or extremities. We sought to examine the molecular landscape of morphea by examining lesional skin gene expression and blood biomarkers and comparing the gene expression profiles with those from site-matched nonlesional and SSc lesional skin. Criteria for histologic differentiation of desmoplastic trichoepithelioma (sclerosing epithelial hamartoma) from morphea-like basal-cell carcinoma. Neurological manifestations: 1 point. Adenomatoid tumors rarely involve the testicular parenchyma and are the most common paratesticular tumor. Subacute: thickened, scaly or excoriated plaques. The tumor cells are typically diffusely positive for CD34 but negative for factor XIIIa. Comment Here. Dysuria, urethral and vaginal discharge, dyspareunia, burning pain, fissuring and erosion may occur. Morphea tends to affect only the outer layers of your skin. Found in epithelium (gallbladder [benign, adenocarcinoma], intestinal metaplasia in stomach) Positive for PAS, Alcian blue at pH 2. Age: fourth to sixth decades (peak fifth) Increased circulating estrogen: Body mass index (BMI): dose response relationship of BMI ≥ 25 and risk of hyperplasia ( Am J Obstet Gynecol 2016;214:689. The nuclei are ovoid and monomorphic, with occasional mitotic activity. Healed ulcer site with wrinkled paper scar. Linear morphea participants with deep involvement were more likely to have a limitation in range of motion (28. It manifests in the first two decades Sep 7, 2023 · Morton neuroma is a degenerative fibrotic neuropathy. Morphea is not the same as scleroderma (systemic sclerosis), and it does not become scleroderma. Sclerema neonatorum. ” Pierini and Vivoli later further described it in 1936, suggesting its possible link to morphea. Specific conditions Erythema nodosum General. White, flat topped papules, plaques or atrophic patches. Affected patients present with single or multiple inflammatory and sclerotic plaques, findings considered manifestations of active disease. Deep involvement was more common in linear (64. Oral psoriasis: red patches, geographic tongue, ulcerations, gingivitis or pustules. The spectrum ranges from relatively mild phenotypes, which generally cause few problems besides local discomfort and visible disfigurement, to subtypes with severe complications such as joint Mar 9, 2023 · Soft tissue, neck, biopsy: Nodular fasciitis (see comment) Comment: This is a spindle stellate cell neoplasm arranged in short bundles and fascicles. The classic histologic features of allergic contact dermatitis are those of a spongiotic dermatitis. Morphea is a cutaneous fibrosing connective tissue disorder that represents a localized form of scleroderma (or systemic sclerosis) occurring primarily in children aged 2-14 years and in women in the fifth decade of life. Overlap can occur where superficial and deep changes co-exist. We present a 26-year-old Caucasian female with a 1. Lichen aureus. 1%, 291/581) in the cohort. Mar 1, 2023 · Definition / general. Jul 1, 2011 · Primary amyloidoisis: masses of eosinophilic, amorphous, fissured material in dermis and subcutaneous tissue. Usually HSV1. Excoriation may result in partial or full thickness epidermal loss (erosion versus ulcer) Often self induced. Most common from of panniculitis. Lamellar ichthyosis: rare inherited skin condition of newborn with shedding of plate-like layers of skin. Need clinical history to distinguish between renal limited IgA nephropathy and systemic HSP. Patients with morphea commonly have systemic symptoms, such as malaise, fatigue, arthralgias, and myalgias, as well as positive autoantibody Sep 1, 2010 · The two viruses are differentiated by culture (difficult to culture zoster) or immunologic methods. Abnormal fibroblast reaction to injury. At puberty, lesions become thicker, more verrucous and hyperpigmented ( Curr Derm Rep 2012;1:186 ) Terms for different clinical patterns. [Google Scholar] . The cellular infiltrate consist of lymphocytes, plasma cells, and histocytic type cells. Purpuric skin lesions on extensor arms and legs and buttocks. Morphoea (American spelling, morphea) is characterised by an area of inflammation and fibrosis (thickening and hardening) of the skin due to increased collagen deposition. Transmitted by the bite of infected female phlebotomine sandflies (infective stage: promastigotes) Promastigotes phagocytized by macrophages and other types of mononuclear phagocytic cells. Acid mucins: Acid-simple non-sulfated: Contain sialic acid. ICD-O: 9230/0 - chondroblastoma, NOS. D. In chronic longstanding allergic contact dermatitis, there can also be psoriasiform changes with marked acanthosis and lesser degrees of spongiosis. It is also known as scleroderma panniculitis . Paul Levins, MD. Fax: 310-794-7005 Phone: 310-825-6911 Email: PLevins@mednet. Nov 10, 2020 · Mucosa may appear grossly unremarkable. um ow qv lh fj ie jd hj sx gl