Recommended: 1 to 2 injections per muscle. Oct 11, 2021 · For some people, Dysport may kick in faster than other injectable neurotoxins. See how to properly prepare Dysport for administration for pediatric patients with upper or lower limb spasticity. To calculate the total units of Dysport Therapeutic required for treatment of one limb, select the dose of Dysport Therapeutic in Units/kg and the body weight (kg) of the patient (Tables 3 and 4). However according to personal preference, it can be mixed witjh 1-5 cc. The efficacy and safety of Dysport were evaluated in a randomized, multicenter, double-blind, placebo-controlled study in 238 adults with upper limb spasticity (ULS) who were at least 6 months post-stroke or post-traumatic brain injury. 5 mL 2. 1 mL; Note: These dilutions are calculated for an injection volume of 0. 7 %âãÏÓ 199 0 obj > endobj 243 0 obj >/Filter/FlateDecode/ID[1C6DF0E8C29EA3C62379675075C69F46>69243412F2173C4BB700B774AD561443>]/Index[199 106]/Info 198 0 Nov 26, 2023 · But there are some notable differences between Botox vs Dysport related to dilution, diffusion, longevity, pricing, and best uses. In my practice, we use a 2 mL dilution, but this can vary (~1-5 mL) based on physician preference. 1 mL Diluent * per 300 Unit Vial Resulting Dose Units per 0. An injection volume 3. . The units are slightly different due to different standards from different laboratories. 6 mL 500 Units 1. Both products are reconstituted the same way: 1 ml of preserved saline to 1 vial. 5cc of Saline to each vial of Botulinum Toxin as suggested in the package insert for a total of 40 units per 1. Joe Niamtu, III DMD. Dysport spreadability. Daher wird empfohlen, bei Lang-zeitbehandlung nicht zwischen unter-schiedlichen Clostridium botulinum Toxin-Präparaten zu wechseln. 0 mL* 100 Dysport and Botox are both mixed with sterile, injectable saline to make them liquids, so that they may be injected. 25/Unit, while Botox and Xeomin are priced higher at ~$12. lovethatface. Includes reconstitution instructions and diluent amounts for both the 300-Unit and 500-Unit vials. Botox is meant for use on glabellar lines, forehead lines, and crow’s feet (laugh lines) around Nov 2, 2009 · Dysport side effects are the same as for other neuromodulators such as Botox or Xeomin. 9% Sodium Chloride Injection, USP using aseptic technique prior to intramuscular injection. For example, Botox costs $10-18 per unit, while Dysport costs $4-7 per unit. 5 mL 200 Units 12 Units 10 Units 50 Units 20 Units 2. BUT – since Dysport is not as concentrated as Botox and Xeomin, it actually takes 2-3 times more units of Dysport to achieve the same therapeutic effect as Botox and Xeomin. 2, Posology and method of administration, in the Summary of Product Characteristics. Into the first 10 mL syringe draw all of Oct 10, 2020 · Dysport is priced at an apparent bargain price of ~$4. Contraindications. Unless for special indications, e. Dysport is used in the Explore Dysport® pediatric spasticity safety data. Cautions. (The proteins are mostly there to stabilize the toxin and improve absorption, Dr. Five syringes are drawn up and each will contain 0. Some physicians use 2 IU (international units) dilution, the package insert recommends 2. Feb 19, 2011 · Each patient is unique, but in most cases, I will start patients out with approximately 30 Dysport units to the horizontal forehead lines, 60 units to the glabella, and 60 units total to the crow's feet (30 units each side) for a total of 150 Dysport units. Studies on the dilution of botulinum toxin with other Jun 25, 2023 · Dysport is meant for use on the vertical lines that form between the eyebrows (glabellar lines). Pooled double-blind trials: below are the most common adverse reactions (≥5%) and greater than placebo in adult patients with cervical dystonia (CD) who received Dysport (500 Units, n=173). and 100 Xeomin and 2 ml standard for 300 U Dysport because we believe this is an optimal concentration for most areas of the face when placed in the muscles 2. 5:1 ratio in clinical practice, one vial of Dysport (500 units) corresponds to two vials of Botox (200 units). 5:1, the adverse event profile was similar in the treatment of CD. Please like and subscribe! IG: nurse_marisa_ Study design for pediatric upper limb spasticity . 5 to 100 U/mL). The dilution ratio of Dysport® in the three included studies were 200U/mL ; 125U/mL, 250U/mL, 375U/mL ; 133U/mL, 200U/mL . The dose used is 600 or 800 units. 1 mL. Natural looking Dysport provides temporary improvement in the appearance of moderate to severe frown lines that are caused by the activity of the procerus and corrugator muscles in patients. 2 DOSE AND METHOD OF ADMINISTRATION THE UNITS OF DYSPORT ARE SPECIFIC TO THE PREPARATION AND ARE NOT INTERCHANGEABLE WITH OTHER PREPARATIONS OF BOTULINUM TYPE A TOXIN. 5mL of saline (120 to 500 U/mL). The study evaluated a total of 208 patients who had a diagnosis of spasticity due to cerebral palsy, were either toxin Mar 4, 2016 · The difference was 20% or higher in nearly half (47%) of the countries. Dysport also remains effective for 3–4 months before follow The recommended dose per side is 30units (60 units for both sides, 0. Training: DYSPORT should only be administered by appropriately trained physicians. One vial of Botox has 100 units and one vial of Dysport has 300 units. 5 mL, providing a total of 600 U of reconstituted Dysport. DYSPORT is intended for intramuscular injection only. IM Focal spasticity Adult Upper limb: Doses of 500-1,000 u divided among selected muscles: Flexor carpi radialis, flexor carpi ulnaris, flexor digitorum profundus, flexor digitorum superficialis, flexor pollicis longus, brachioradialis, pronator teres: 100-200 u; adductor pollicis: 25-50 u; brachialis, biceps brachii: 200-400 u; triceps brachii, pectoralis major, subscapularis, latissimus Pediatric Spasticity Dosing and Dilution Webinar . 5 ml of 0. Before you receive a Dysport injection tell your doctor: Feb 26, 2021 · This generates and determines a dilution effect. This difference means that you will need to use more units of Dysport to achieve the same results as you would with Botox, and the cost may rival your Sep 28, 2023 · DYSPORT is supplied as a dry powder, in single-dose 300 Unit and 500 Unit vials, which must be reconstituted with preservative-free 0. Simple Dysport Dosing (Table 1) A thorough understanding of Dysport dosing is a pre-requisite for integrative treatment. The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin reaction, upper respiratory infection, Dec 22, 2022 · What really sets Dysport apart is its spreadability. The dilution methods are specific to this toxin. While this isn’t a problem for some people, it is essential to consider that three Dysport units equal about one unit of Botox. The ratio: 1 ml of preserved saline : to one vial of Dysport (300 Jun 18, 2021 · It is assumed that the greater dilution for larger muscles may produce better therapeutic effects than the low diluted volume, but there has been no evidence to prove it . We use 3 IU !!! To put that in English, we use 33% more than someone injecting the 2 IU dilution and 17% more than the recommended dosage. 0 mL* 100 Units Diluent per Dysport 300-Unit Vial Resulting Dysport Units per 0. The desired final concentration after dilution varies depending on the indication (see Table 2 for the recommended solution concentration after dilution). 0 mL 2. What Dysport is used for: Adults: Dysport is used in adults to treat muscle spasms: • Around the eyes • In the face • In the neck • In the arm and shoulders • In the leg Dysport is also used in adults to treat: • Hyperhidrosis. Here I’m showing the most common dilutions with the most common syrin Jul 28, 2019 · Wouldn't it be great if you didn't have to do mental math gymnastics when switching back and forth between Botox and Dysport? In this short video I'll show Jun 2, 2010 · Answer: Botulinum Toxin (Dysport or Botox) dilution and preparation We use 2. Skin Caution should be exercised when administering DYSPORT AESTHETIC™ to patients with May 14, 2023 · No study has assessed the effects of the incorporation of isolated lidocaine into botulinum toxin for reducing its pain or complications. “Many people report that it lasts longer than other neuromodulators," says Dr. 5 ml 0. com Botox & Dysport come in a powder and then we add saline to it before injection the same day. A dilution of 100 MU of ONA/INCO in 2. 0 mL Feb 15, 2001 · In terms of clinical efficacy in humans, 1 U of Botox is estimated to be equal to 3 to 4 U of Dysport, the product used in our study. How to store Dysport 6. 0 mL Dec 5, 2014 · First, our study shows that Dysport treatment results were not inferior to those from Botox at a conversion factor of 2. What Dysport is and what it is used for Dysport is a medicine that blocks the transmission of nerve impulses to the muscle or sweat glands so that spasms in the muscle or sweat production is reduced. Diluent is sterile, preservative-free 0. Higher conversion ratios may lead to an overdosing of Dysport, with a potential increased incidence of adverse events. 5 mL 3. 0 mL 0. How Dysport is given How to use it Your doctor will make up and give you the injection. Die Einheiten von Dysport sind spezifisch für das Präparat Dysport und dürfen nicht auf andere Präparate mit dem Wirkstoff Clostridium botulinum Toxin übertragen werden. 20,33,34 On the basis of previously reported clinical Note: These dilutions are calculated for an injection volume of 0. The biggest difference comes in the formulations of both injectables. Leave a comment if any questions. Dysport is much more diluted and spreads quickly compared to Botox. In 2. Table 1 provides dilution instructions • For additional information, refer to Table 1: Dilution Instructions for Dysport Vials (500 Units and 300 Units) in package insert Section 2. Feb 2, 2022 · “ Dilution Calc” AppEasy to use app for Neurotoxin counting. www. Dysport darf nur von Ärzten angewendet . The Dysport is a local muscle relaxant (or neuromuscular blocking agent) adapted from the botulinum neuromodulator type-A and is used in both aesthetic and therapeutic indications. The article discusses the available evidence on the conversion ratio between Dysport and Botox in adults affected by spasticity, cervical dystonia for the 300 Unit and 500 Unit vials, depending on the desired final concentration. Azzalure is indicated for the temporary improvement in the appearance of moderate to severe glabellar lines (vertical lines between the eyebrows, or “frown lines”) seen at frown and lateral canthal lines (crow’s feet lines) seen at maximum smile, in adult patients under 65 years, when the severity of Apr 21, 2021 · 4. The extra dilution of Dysport means it tends to spread slightly further than Botox. , curare-like Administration: Dysport should only be injected by appropriately trained physicians. 05 mL of reconstituted BICEPS BRACHII Dysport 200 to 400 Units. 00/Unit. Taken together, the findings retrieved from this literature research suggest that a conversion ratio of 3:1 (Dysport:Botox)--or even lower--can be considered appropriate for the treatment of the above-mentioned conditions. In-person or virtual mentorship on Dysport injection, dosing and dilution, and appropriate use. Note: These dilutions are calculated for an injection volume of 0. Administer Dysport within 4 hours of reconstitution. 7%) in the saline assay. 1 Dysport helps them look consistently natural—not frozen—because it allows the untreated facial muscles to work normally, which in turn helps patients freely show facial expressions in untreated areas. Which looks more natural BOTOX® or Dysport? Dysport is composed of smaller molecules, which may allow it to spread to a wider area and provide a more natural-looking result. 1 mL Resulting Dysport Units per 1. 08 mL (20% decrease in Safety results in adult cervical dystonia . 2 Preparation of DYSPORT Solution for Administration DYSPORT is supplied as a dry powder, in single-dose 300 Unit and 500 Unit vials, which must be reconstituted with preservative-free 0. 15 mL (50% increase in dose)). Dysport is given as an injection in the muscle (intramuscularly), or under the skin (subcutaneously) after dilution, depending on the condition for which you are being treated. DYSPORT is contraindicated in patients with known hypersensitivity to any botulinum toxin products, cow’s milk protein, or to any of the components in the formulation, or infection at the proposed injection site(s). 5. However, a single Botox unit’s potency is nearly three times stronger than Dysport. 6 %âãÏÓ 457 0 obj > endobj 479 0 obj >/Filter/FlateDecode/ID[]/Index[457 54]/Info 456 0 R/Length 102/Prev 649547/Root 458 0 R/Size 511/Type/XRef/W[1 2 1 Oct 23, 2023 · On average, Dysport may cost slightly less than Botox per treatment area due to the different dilution ratios. Jede Sprit-ze ist entsprechend zu kennzeichnen. Dysport is given by intramuscular injection. 2 Preparation of Dysport Solution for Administration DYSPORT is supplied as a dry powder, in single-dose 300 Unit and 500 Unit vials, which must be reconstituted with preservative-free 0. This may cause some confusion for clinicians not adept at determining how many units to inject in each anatomical area. 0 cc. 1 * This will result in two 10 mL syringes, each containing 7. For the treatment of focal spasticity, Dysport can also be administered by healthcare professionals having received appropriate training and qualification in accordance with national guidelines (e. To find out more about Botox, Dysport and cosmetic facial surgery in Richmond, Virginia visit www. Dysport is not interchangeable with other botulinum toxins, and the potency units are not the same 1 In the Botox vs Dysport debate, you’ll come to find that it’s really difficult to compare the two injectables. 5 mL 120 Units 3. Modified Ashworth Scale (MAS) score was ≥2 in the primary target muscle group (PTMG) for toxin-naive patients Dysport tends to be less expensive per unit than Botox. I find it more logical to think directly in Dysport Units, with 10 DU being a Contraindications. These volumes yield concentrations specific for the use for each indication (see Table 1). When using the 2. 2 Dysport is a prescription injection for temporary improvement in the look of moderate to severe frown lines between the eyebrows (glabellar lines) in adults less than 65 years of age. %PDF-1. 0 mL of diluent should be used. 6 mL 1. Contents of the pack and other information 1. Cosmetic Facial Surgery Dosing and Dilution Dysport offers the flexibility to retreat patients every 12 to 16 weeks or longer, as necessary, based on the return of clinical symptoms. This was first shown by Hambleton and Pickett,4 who measured different samples of Botox and Dysport usingthetwoassays:aBotoxunitwasapproximately 3 times more potent in the Dysport assay, and a Dysportunitwasapproximately2. foryourbestself. Dysport Therapeutic dosing for spasticity in pediatric patients is based on Units per kilogram of body weight. However, this dilution has resulted in more cost effectiveness. Dysport während einer Behandlungssit-zung angewendet werden, muss darauf geachtet werden, die korrekte Menge an Lösungsmittel zur Auflösung zu ver-wenden. Dec 13, 2018 · The total Clostridial protein content of the three main commercially available BoNT-A products—Dysport ®, Botox ®, and Xeomin ® —has been previously reported in the literature, giving values of 5 ng per 100 U vial of Botox, 4. 05 mL (50% decrease in dose), 0. Watch Now How Dysport is given . Table 1 provides dilution instructions Dysport contains the active substance Clostridium botulinum type A toxin-haemagglutinin complex. Three hundred units of abobotulinumtoxinA (Dysport®) may be diluted in 0. Table 1: Dilution Instructions for DYSPORT Vials (500 Units and 300 Units) Diluent* per 500 Unit Vial When fully reconstituted, Dysport should be a clear, colorless, and particulate-free solution. DYSPORT AESTHETIC™ Product Monograph Page 6 of 25 The potential risk of localised muscle weakness or visual disturbances linked with the use of DYSPORT ™ AESTHETIC may temporarily impair the ability to drive or operate machinery. With Dysport the same is true and it can be diluted to different strengths. This can make it easier to treat larger areas as it means fewer injections are required. 1 * Diluent is sterile, Preservative-free 0. Doft says. 9 % sodium chloride for injection). These potential side effects or complications include injection site discomfort, headache, bruising, swelling, eyelid droop (ptosis), local reactions, systemic reactions, and unsatisfactory cosmetic results. DILUTION. e. 3mL 0 of reconstituted solution) of DYSPORT, to be divided into 3 injection sites; 10units (0. The package insert of onabotulinumtoxinA (Botox®) recommends dilution of 100 units in 1 to 8mL of saline (12. g. Table 1: Dilution Instructions for DYSPORT Vials (500 Units and 300 Units) Diluent* per 500 Unit Vial Note: These dilutions are calculated for an injection volume of 0. Second, at the ratio of 2. Azzalure is the aesthetic version of Dysport for the European Union member states. 9% sodium chloride injection to yield a solution of Dysport with a concentration equivalent to 200 units in 1 ml. , treatment of hyperhidrosis, dilutions should not vary to increase patient safety. However, more Dysport units may be required to achieve the same results as Botox. The safety of DYSPORT for the treatment of hyperhidrosis has not been established. FAQ Sep 30, 2023 · Note: These dilutions are calculated for an injection volume of 0. Dysport 300-Unit Vial: Recommended dilution options1 Dysport 500-Unit Vial: Recommended dilution options1 2. 5 IU. Reconstitution instructions are specific for each of the 300 Unit vial and the 500 Unit vial. Pre-existing Conditions at the Injection Site. 08% (20% decrease in dose) or 0. 08 mL (20% decrease in For the mouse assay used to standardize each batch of Dysport, the toxin is diluted in a phosphate buffer containing gelatine that stabilizes the toxin at low concentrations, whereas saline is used as the diluent for the Botox assay, which gives a loss of potency because of dilution artefacts. Dysport 50 Units Dysport 25 Units Dysport 20 Units 1. Study design for adult upper limb spasticity . Dysport is indicated for the temporary improvement in the appearance of moderate to severe glabellar lines associated with procerus and corrugator muscle activity in Oct 9, 2019 · What is the reconstitution ratio for Botox/Dysport? Many practitioners ask if Dysport is reconstituted differently than Botox. Jan 24, 2016 · The products are very similar. AN APPROACH FOR THE DILUTION OF DYSPORT® (abobotulinumtoxinA ) Dysport 50 Units Dysport 20 Units Dysport 12 Units Dysport 10 Units Dysport 500 Units Dysport 200 Units Dysport 120 Units Dysport 100 Units 0. For the injection, Dysport will be dissolved in 0. Table 1 provides dilution instructions for the 300 Unit and 500 Unit vials, depending on the desired final concentration. , 0. According to the manufacturer’s instruction, the Dec 6, 2015 · The dilution volume varies widely. 2: Preparation of Dysport Solution for Administration1 Drug Interactions Co-administration of Dysport and amino-glycosides or other agents interfering with neuromuscular transmission (e. The added spreadability can slightly increase the risk of the product unintentionally affecting the eyelids and eyebrow if administered by an The Dysport Injector Locator is designed to make it easy for patients, caregivers, and referring physicians to find injectors in their area who are trained to administer botulinum toxins, including Dysport. This is a Strategy 2. 35 ng per 500 U vial of Dysport (correcting an earlier publication stating 12. †When econsr i t tuting a 500-Unit vial of Dysport in preparation for dilution, no more than 2. The important thing to understand is that it is not the dilution but rather the number of units injected which affects your result. Dosing of Dysport is easily mastered, whether you prefer to think directly in Dysport Units (DU) or to convert from Botox Units (BU). When administering Dysport in adult spasticity, re-treatment should occur May 14, 2022 · This DILUTIONCALC app is no longer available for downloads but still works on my phone. While 50 units of Botox® costs $500, 125 units of Dysport® costs $450. Hypersensitivity. Adverse Reactions When treating excessive sweating, Dysport 500 units is diluted with 2. DYSPORT is approved only for intramuscular injection. 5 mL 200 Units 5. Cho, and recent studies by Galderma show that Dysport may last up to five months. How to use Dysport 4. Dysport ® has a wide FDA-approved dosing range, allowing for flexibility to customize subsequent doses based on patient response,. Table l: Dilution Instructions for DYSPORT Vials (500 Units and 300 Units) 2. Dysport® is diluted more than Botox®. Dysport dosing for adult ULS in the pivotal clinical trial. In the open-label extension, the SOCs and PTs most frequently associated with TEAEs were infections and infestations, followed by general disorders and administration site conditions, respiratory, thoracic and mediastinal disorders, gastrointestinal disorders and musculoskeletal and connective tissue disorders. loss of potency because of dilution artefacts. 9% sodium chloride injection. 5 ng per 500 U vial), and Xeomin Do not receive a Dysport injection if: you are allergic to Dysport or any of its ingredients, or cow’s milk protein; you had an allergic reaction to any other botulinum toxin product, such as Myobloc®, Botox®, or Xeomin®; or you have a skin infection at the planned injection site. , Royal College of Physicians). Your doctor will make up and give you the injection. Units shown indicate the average Dysport dose and specific muscles injected. Doshi explains, the specific protein used in Dysport has a lower molecular weight than the protein used in Botox, allowing a Dysport injection to diffuse through tissues. Allergy to cow milk protein. 9% Sodium Chloride Injection USP. For further information see Section 4. 6 cc or 60 units. 08 mL (20% decrease in dose) or 0. The conversions is about 2. Sensitivity analyses considering available “real-world” dosing showed consistent results, with Dysport being less costly than Botox in all 19 countries. 9% Sodium Chloride Injection, USP. 5 units of dysport per unit of botox to get similar results. 9% NaCl/H 2 O produces volumes that are easily injectable and adequate in relation to the target muscle volume. If you think your patients may benefit from having a Dysport injection specialist on their care team, start your search today. Once reconstituted, Dysport should be stored in a refrigerator (2-8° C; 36- 46° F), protected from light, and used within four hours. Dysport may create a more natural look than other neuromodulators. Sep 30, 2023 · DYSPORT is supplied as a dry powder, in single-dose 300 Unit and 500 Unit vials, which must be reconstituted with preservative-free 0. A decrease or increase in the DYSPORT dose is also possible by administering a smaller or larger injection volume (i. As Dr. 4 Dosing in Spasticity in Adults Dosing in nitlal and subsequent treatment sessions should be tailored to the individual based on the Size, number and location of muscles involved, severity of spasticlty, he Apr 11, 2013 · The optimal conversion ratio between Dysport and Botox—the two botulinum neurotoxin type A products (BoNT-As) supported by the larger bulk of evidence—has been extensively debated, because of its broad medical and economic implications. com. Dilution instructions for a dose of 800 U • Using 300 U vials: Reconstitute three 300 U vials each with 1. Dysport is cheaper than Botox because of the dilution in Dysport. Before you receive a Dysport injection tell your doctor: Sep 28, 2023 · Table 1: Dilution Instructions for DYSPORT Vials (500 Units and 300 Units) Diluent * per 500 Unit Vial Resulting Dose Units per 0. ) Note: These dilutions are calculated for an injection volume of 0. Both Dysport and Botox are effective in reducing moderate to severe wrinkles and fine lines. The efficacy and safety of Dysport were evaluated in a randomized, prospective, double-blind, multicenter, low-dose controlled, multiple treatment study with pediatric patients aged 2 to 17 with upper limb spasticity (ULS). We believe that looking your absolute best changes the way you fe Apr 1, 2024 · Dysport® (abobotulinumtoxin A) is a botulinum toxin recently indicated in the treatment of neurological detrusor overactivity secondary to spinal cord injury or multiple sclerosis, in patients with intermittent self-catheterization. How to use it . Die zuzugebende Menge iso-toner Natriumchloridlösung ist für Dysport 300 Einheiten und Dysport 500 Einheiten verschieden. 6 to 2. There is no such thing as a treatment be Dysport Product Information: Version 6, 21 July 2020 2 4. 5:1. Do not freeze reconstituted Dysport. Caution should be exercised when DYSPORT is used where the targeted muscle shows excessive weakness or atrophy. 5 mL of preservative-free saline solution (0. 08 mL (20% decrease in Do not receive a Dysport injection if: you are allergic to Dysport or any of its ingredients, or cow’s milk protein; you had an allergic reaction to any other botulinum toxin product, such as Myobloc®, Botox®, or Xeomin®; or you have a skin infection at the planned injection site. 5timeslesspotent (activity declined to 39. Injection site infection. 0 mL* Diluent per Dysport 300-Unit Vial Resulting Dysport Units per 0. 3 to 4 hours; Faculty observes you during injection treatment sessions; Mar 24, 2021 · About APT Medical AestheticsWe are passionate about helping our clients change their lives. The authors concluded that substantial savings could be realized by using Dysport to treat upper limb spasticity. Possible side effects 5. Exercise caution when administering to patients with surgical alterations to facial anatomy, excessive weakness or atrophy in the target muscle(s), marked facial asymmetry, inflammation at the injection site(s), ptosis, excessive dermatochalasis, deep dermal scarring, thick sebaceous skin or Nov 22, 2009 · To prepare Dysport for this dilution, 3 cc of preserved saline is added to the 300 unit Dysport vial. xb hd an jp cf nd lf mv yg kw